r.weights.delta {MRZero} | R Documentation |
Calculates p-values for penalization of weights with second-order weights
Description
Internal function for calculating penalized weights in conjunction with penalised.weights
with weights
equal to "delta"
.
These weights are used in either the mr_ivw
or mr_egger
functions when penalized = TRUE
.
Usage
r.weights.delta(.Bx, .Bxse, .By, .Byse, .psi, .pen.weights)
Arguments
.Bx |
Beta-coefficient for genetic association with the risk factor. |
.Bxse |
Standard error of genetic association with the risk factor. |
.By |
Beta-coefficient for genetic association with the outcome. |
.Byse |
Standard error of genetic association with the outcome. |
.psi |
The correlation between the genetic associations with the exposure and the association with the outcome for each variant resulting from sample overlap. |
.pen.weights |
Factors for penalizing weights. |
Details
None.
Value
Penalized weights.
Examples
r.weights.delta(ldlc, ldlcse, chdlodds, chdloddsse, 0,
penalised.weights.delta(ldlc, ldlcse, chdlodds, chdloddsse, 0))
[Package MRZero version 0.2.0 Index]