pgo_tte {drugdevelopR}R Documentation

Probability to go to phase III for multiarm programs with time-to-event outcomes

Description

Given our parameters this function calculates the probability to go to phase III after the second phase was conducted. The considered strategies are as follows:

Usage

pgo_tte(HRgo, n2, ec, hr1, hr2, strategy, case)

Arguments

HRgo

threshold value for the go/no-go decision rule

n2

total sample size in phase II, must be divisible by 3

ec

control arm event rate for phase II and III

hr1

assumed true treatment effect on HR scale for treatment 1

hr2

assumed true treatment effect on HR scale for treatment 2

strategy

choose Strategy: 1 ("only best promising"), 2 ("all promising")

case

different cases: 1 ("nogo"), 21 (treatment 1 is promising, treatment 2 is not), 22 (treatment 2 is promising, treatment 1 is not), 31 (both treatments are promising, treatment 1 is better), 32 (both treatments are promising, treatment 2 is better)

Value

The function pgo_tte() returns the probability to go to phase III.

Examples

res <- pgo_tte(HRgo = 0.8, n2 = 48 , ec = 0.6, hr1 = 0.7, hr2 = 0.8, strategy = 2, case = 31)

[Package drugdevelopR version 1.0.2 Index]