anesthesia {netdose}R Documentation

Anesthesia Dataset for Dose-Response Network Meta-Analysis

Description

This dataset is a synthesis of randomized controlled studies investigating the effects of different agents for preventing vomiting within 24 h postoperatively in adults after general anaesthesia. Multicomponent interventions have been excluded from this subset to focus on single-agent interventions and their dose-response relationships.

Usage

anesthesia

Format

A data frame with the following columns:

agent1 Character vector indicating the name of the agent in arm 1.
agent2 Character vector indicating the name of the agent in arm 2.
agent3 Character vector indicating the name of the agent in arm 3.
agent4 Character vector indicating the name of the agent in arm 4.
agent5 Character vector indicating the name of the agent in arm 5.
event1 Integer vector for the number of participants who experienced vomiting in arm 1.
event2 Integer vector for the number of participants who experienced vomiting in arm 2.
event3 Integer vector for the number of participants who experienced vomiting in arm 3.
event4 Integer vector for the number of participants who experienced vomiting in arm 4.
event5 Integer vector for the number of participants who experienced vomiting in arm 5.
n1 Integer vector for the total number of participants in study arm 1.
n2 Integer vector for the total number of participants in study arm 2.
n3 Integer vector for the total number of participants in study arm 3.
n4 Integer vector for the total number of participants in study arm 4.
n5 Integer vector for the total number of participants in study arm 5.
dose1 Numeric vector specifying the dose level in arm 1.
dose2 Numeric vector specifying the dose level in arm 2.
dose3 Numeric vector specifying the dose level in arm 3.
dose4 Numeric vector specifying the dose level in arm 4.
dose5 Numeric vector specifying the dose level in arm 5.
studyid Character vector with unique study identifiers.

Details

The dataset includes data on several agents for preventing vomiting and their observed effects across multiple clinical randomized controlled trials. The outcome is the occurrence of vomiting within 24 hours after surgery. By excluding multicomponent interventions, this subset allows for a more precise evaluation of single-agent dose-response relationships.

The dataset is structured in a contrast-based format and includes the following variables:

This dataset is intended for use in dose-response network meta-analysis to explore the effects of single agents across various doses.

Source

The dataset is a subset of data derived from: Weibel S, Rücker G, Eberhart LHJ, et al. Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis. Cochrane Database of Systematic Reviews. 2020;10(10):CD012859. Weibel S, Schaefer MS, Raj D, et al. Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: an abridged Cochrane network meta-analysis. Anaesthesia. 2021;76:962-973.

Examples


data(anesthesia)
# Summarize the dataset
summary(anesthesia)


[Package netdose version 0.6-0 Index]