stemcells {jarbes} | R Documentation |
Meta-analysis: 31 randomized controled trials (RCTs) with reported discrepancies
Description
Meta-analysis of 31 randomized controled trials (RCTs) of two treatment groups of heart disease patients, where the treatment group received bone marrow stem cells and the control group a placebo treatment.
Format
A matrix with 31 rows and 11 columns. Each row represents study results, the columns are:
- trial
ID name of the trial.
- effect.size
treatment effect is measured as the difference of the ejection fraction between groups, which measures the improvement of left ventricular function in the heart.
- se.effect
Standard Error of the effect.size.
- sample.size
Total number of patients in the trial.
- n.discrep
Number of detected discrepancies in the published trial. Discrepancies are defined as two or more reported facts that cannot both be true because they are logically or mathematically incompatible.
- Sequence
Bias arising from the randomization process.
- Allocation
Bias due to deviations from intended interventions.
- Blinding
Bias introduced by lack of blinding.
- Outcome
Bias in measurement of the outcome.
- Reporting
Bias in selection of the reported result.
- Other
Selection bias, performance bias, detection bias, attrition bias, etc.
Source
Nowbar, A N, et al. (2014) Discrepancies in autologous bone marrow stem cell trials and enhancement of ejection fraction (DAMASCENE): weighted regression and meta-analysis. BMJ, 348,1-9.
References
Verde, P. E. (2017) Two Examples of Bayesian Evidence Synthesis with the Hierarchical Meta-Regression Approach. Chap.9, pag 189-206. Bayesian Inference, ed. Tejedor, Javier Prieto. InTech.