ObsTime.TwoArm {ClinTrialPredict} | R Documentation |
Calculate the observation time for a two-arm clinical trial
Description
predicting two-arm clinical trial
Usage
ObsTime.TwoArm(
N.0 = NULL,
N.1 = NULL,
ratio = NULL,
d = NULL,
gamma.c = NULL,
alpha0.t = NULL,
nu0.t,
alpha1.t,
nu1.t,
s,
m,
design2 = NULL
)
Arguments
N.0 |
number of subjects plan to be enrolled in control arm |
N.1 |
number of subjects plan to be enrolled in experimental arm |
ratio |
randomization ratio between two arms: |
d |
expected number of events observed at time |
gamma.c |
parameter of the exponential distribution of censoring time |
alpha0.t |
shape parameter of weibull survival distribution for control arm |
nu0.t |
scale parameter of weibull survival distribution for control arm |
alpha1.t |
shape parameters of weibull survival distribution for experimental arm |
nu1.t |
scale parameter of a weibull survival distribution for control arm |
s |
enrollment time |
m |
maximum follow-up time for a subject |
design2 |
a list containing all the above parameters for two-arm design |
Value
This function returns a list containing all design parameters, including the calculated observation time l
Examples
# calculate the observation time
ObsTime.TwoArm(N.0=100,N.1=100,d=10,gamma.c=1,alpha0.t = 1,nu0.t=5,alpha1.t=2,nu1.t=4,s=5,m=4)