dtl_tier_the {dtlcor} | R Documentation |
Theoretical family-wise type I error rate (FWER) given a fixed correlation coefficient under drop-the-losers (DTL) design
Description
Get the theoretical FWER alpha given fixed correlation coefficient
Usage
dtl_tier_the(n, t, rho, q, alpha_s, delta)
Arguments
n |
Sample size per arm at DTL look |
t |
A vector of information fraction of final stage |
rho |
Fixed correlation coefficient |
q |
Response rate under the null |
alpha_s |
Significance level for the final stage |
delta |
Least difference to decide superiority of high dose |
Value
Theoretical FWER alpha
Examples
# Without interim analysis
dtl_tier_the(n = 80, t = 1, rho = 0.4, q = 0.3, alpha_s = 0.025, delta = 0.05)
# With interim analysis
dtl_tier_the(n = 80, t = c(0.5, 1), rho = c(0.4, 0.2), q = 0.3, alpha_s = 0.025, delta = 0.05)
[Package dtlcor version 0.1.0 Index]