dtl_cor_the_PH_upper_bound {dtlcor} | R Documentation |
Theoretical upper bound of correlation coefficient between time-to-event primary endpoint and binary surrogate endpoint
Description
Get theoretical upper bound of correlation coefficient
Usage
dtl_cor_the_PH_upper_bound(tau_k, pi_ar = 0.5, q, gamma)
Arguments
tau_k |
Equals n/n_k, where n is the number of patients per treatment arm at the DTL look and n_k is the number of patients in both selected and control arms at the kth interim analysis. |
pi_ar |
Allocation rate of treatment and control (0.5 by default) |
q |
Response rate under the null |
gamma |
Hazards ratio of responders and non-responders |
Value
Theoretical upper bound of correlation coefficient
Examples
dtl_cor_the_PH_upper_bound(tau_k = 0.4, pi_ar = 0.5, q = 0.3, gamma = 0.2)
[Package dtlcor version 0.1.0 Index]