dtl_tier_the {dtlcor}R Documentation

Theoretical family-wise type I error rate (FWER) given a fixed correlation coefficient under drop-the-losers (DTL) design

Description

Get the theoretical FWER alpha given fixed correlation coefficient

Usage

dtl_tier_the(n, t, rho, q, alpha_s, delta)

Arguments

n

Sample size per arm at DTL look

t

A vector of information fraction of final stage

rho

Fixed correlation coefficient

q

Response rate under the null

alpha_s

Significance level for the final stage

delta

Least difference to decide superiority of high dose

Value

Theoretical FWER alpha

Examples


# Without interim analysis
dtl_tier_the(n = 80, t = 1, rho = 0.4, q = 0.3, alpha_s = 0.025, delta = 0.05)

# With interim analysis
dtl_tier_the(n = 80, t = c(0.5, 1), rho = c(0.4, 0.2), q = 0.3, alpha_s = 0.025, delta = 0.05)



[Package dtlcor version 0.1.0 Index]