dtl_cor_the_PH_upper_bound {dtlcor}R Documentation

Theoretical upper bound of correlation coefficient between time-to-event primary endpoint and binary surrogate endpoint

Description

Get theoretical upper bound of correlation coefficient

Usage

dtl_cor_the_PH_upper_bound(tau_k, pi_ar = 0.5, q, gamma)

Arguments

tau_k

Equals n/n_k, where n is the number of patients per treatment arm at the DTL look and n_k is the number of patients in both selected and control arms at the kth interim analysis.

pi_ar

Allocation rate of treatment and control (0.5 by default)

q

Response rate under the null

gamma

Hazards ratio of responders and non-responders

Value

Theoretical upper bound of correlation coefficient

Examples

dtl_cor_the_PH_upper_bound(tau_k = 0.4, pi_ar = 0.5, q = 0.3, gamma = 0.2)


[Package dtlcor version 0.1.0 Index]