%global __brp_check_rpaths %{nil} %global __requires_exclude ^libmpi %global packname SynergyLMM %global packver 1.0.0 %global rlibdir /usr/local/lib/R/library Name: R-CRAN-%{packname} Version: 1.0.0 Release: 1%{?dist}%{?buildtag} Summary: Statistical Framework for in Vivo Drug Combination Studies License: GPL (>= 3) URL: https://cran.r-project.org/package=%{packname} Source0: %{url}&version=%{packver}#/%{packname}_%{packver}.tar.gz BuildRequires: R-devel >= 4.0 Requires: R-core >= 4.0 BuildArch: noarch BuildRequires: R-CRAN-ggplot2 >= 3.5.1 BuildRequires: R-CRAN-nlme >= 3.1.165 BuildRequires: R-CRAN-magrittr >= 2.0.3 BuildRequires: R-CRAN-dplyr >= 1.1.4 BuildRequires: R-CRAN-cowplot >= 1.1.3 BuildRequires: R-CRAN-rlang BuildRequires: R-CRAN-nlmeU BuildRequires: R-CRAN-fBasics BuildRequires: R-CRAN-car BuildRequires: R-CRAN-MASS BuildRequires: R-CRAN-performance BuildRequires: R-CRAN-lattice BuildRequires: R-CRAN-marginaleffects BuildRequires: R-CRAN-clubSandwich Requires: R-CRAN-ggplot2 >= 3.5.1 Requires: R-CRAN-nlme >= 3.1.165 Requires: R-CRAN-magrittr >= 2.0.3 Requires: R-CRAN-dplyr >= 1.1.4 Requires: R-CRAN-cowplot >= 1.1.3 Requires: R-CRAN-rlang Requires: R-CRAN-nlmeU Requires: R-CRAN-fBasics Requires: R-CRAN-car Requires: R-CRAN-MASS Requires: R-CRAN-performance Requires: R-CRAN-lattice Requires: R-CRAN-marginaleffects Requires: R-CRAN-clubSandwich %description A framework for evaluating drug combination effects in preclinical in vivo studies. 'SynergyLMM' provides functions to analyze longitudinal tumor growth experiments using linear mixed-effects models, perform time-dependent analyses of synergy and antagonism, evaluate model diagnostics and performance, and assess both post-hoc and a priori statistical power. The calculation of drug combination synergy follows the statistical framework provided by Demidenko and Miller (2019, ). The implementation and analysis of linear mixed-effect models is based on the methods described by Pinheiro and Bates (2000, ), and GaƂecki and Burzykowski (2013, ). %prep %setup -q -c -n %{packname} # fix end of executable files find -type f -executable -exec grep -Iq . {} \; -exec sed -i -e '$a\' {} \; # prevent binary stripping [ -d %{packname}/src ] && find %{packname}/src -type f -exec \ sed -i 's@/usr/bin/strip@/usr/bin/true@g' {} \; || true [ -d %{packname}/src ] && find %{packname}/src/Make* -type f -exec \ sed -i 's@-g0@@g' {} \; || true # don't allow local prefix in executable scripts find -type f -executable -exec sed -Ei 's@#!( )*/usr/local/bin@#!/usr/bin@g' {} \; %build %install mkdir -p %{buildroot}%{rlibdir} %{_bindir}/R CMD INSTALL -l %{buildroot}%{rlibdir} %{packname} test -d %{packname}/src && (cd %{packname}/src; rm -f *.o *.so) rm -f %{buildroot}%{rlibdir}/R.css # remove buildroot from installed files find %{buildroot}%{rlibdir} -type f -exec sed -i "s@%{buildroot}@@g" {} \; %files %{rlibdir}/%{packname}